Gastrointestinal side effects like nausea, vomiting, reflux, diarrhoea, and constipation are common with novel weight loss treatments like tirzepatide (Mounjaro) and semaglutide (Ozempic or Wegovy). However, these symptoms should not be ignored, both to ensure there is no underlying worrying cause, and to get symptoms under control so people can continue on their weight loss journey.